Name:	Glycolic acid; Glycolic acid;
Cas No.：	79-14-1
Formula:	C2H4O3
Molecular weight：	76.05
EINECS：	201-180-5
Struction：

Chemical properties:

Nature: 70% high purity grade for colorless liquid, 70% industrial grade for amber liquid.

Melting point: 80℃

Boiling point: 112℃(decomposition)

Flash point: 300℃(decomposition)

Freezing point: 10℃

Relative density: 1.25

Solubility: Soluble in water, ethanol and ether.

Security information:

Dangerous Goods Transport number: UN3265

Product use:

1. Mainly used as beauty skin care products, with deep skin cleaning and moisturizing effect;

2. This product can be used for QingXiYe, for some metals composition has better cleaning function, but also for equipment material corrosion resistance is extremely low, high efficiency, low cost;

3. Raw materials of organic synthesis can be used to produce fiber dyeing agent, leather dyeing agent, tanning agent, welding agent ingredients, varnish ingredients, copper etching agent, adhesive, electroplating agent, oil demulsifier and metal chelating agent, etc.

4. In addition, this product can be used as electroplating additive; It can also be used as a chemical analysis reagent.

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Medical application

Percutaneous intra - tumor injection is an important means to treat liver cancer. Acetic acid is an effective intra - tumor injection therapy. However, percutaneous acetic acid injection in the treatment of liver cancer is still limited in the penetration of tumor, difficult to make sustained release preparations, and causes pain in patients during injection. In order to overcome this shortcoming, glycolic acid was introduced into the treatment of liver cancer by intraperitoneal injection as a highly effective chemical inactivator. Through the study on the treatment of tumor cells in vitro, liver necrosis in rats and transplanted liver cancer in nude mice, glycolic acid proved to have a strong antitumor effect. At the same time, glycolic acid was prepared into liposomes and chitosan modified liposomes were prepared. The encapsulation rate and release in vitro were investigated, and the therapeutic effect of glycolic acid liposomes on transplanted tumors in nude mice was studied. [8]

In the pharmacodynamic investigation of glycolic acid solution, different concentrations of glycolic acid solution were prepared, and the cell, rat and nude rat experiments were carried out, and the pharmacodynamic of glycolic acid solution with the same concentration was compared. Through cell experiment, it was found that glycolic acid had strong inhibitory effect on liver tumor cells. Compared with acetic acid at the same concentration, the mean diameter of the maximum cross section of liver necrosis caused by glycolic acid was larger (P 0.05). In the experimental treatment of transplanted tumor in nude mice, the mean diameter of nude mice after transdermal injection of acetic acid was smaller than that of acetic acid with the same concentration (P 0.05), and the stronger inhibitory effect of acetic acid was further confirmed by light microscopy and electron microscopy.

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