Natamycin is a white to milky white odorless and tasteless crystalline powder produced by controlled fermentation of Streptomyces natalis. It usually exists in the form of enol. Its mechanism of action is to unite with ergosterol and other sterol groups of fungi, to inhibit ergosterol biosynthesis, so as to distort cell membranes and eventually lead to leakage and cell death. Natamycin can obviously prolong the shelf life of dough when it is used to treat the surface of dough in baked food.

Natamycin, as a microbial preservative, has attracted much attention due to its safety, natural and healthy characteristics. Natamycin has many advantages: prolonging the shelf life of food, preventing the deterioration caused by yeast and mould;

Reduce food recycling caused by deterioration and reduce production costs;

To meet consumers'requirements for natural food;

Do not change the flavor of food;

Low dose and high efficiency;

The antimicrobial effect lasts a long time.

Food use

Natamycin is a natural, broad-spectrum, efficient and safe filamentous fungal inhibitor, which can not only inhibit fungi, but also prevent the production of mycotoxins. Natamycin is harmless to human body, difficult to be absorbed by human digestive tract, and it is difficult for microorganisms to resist it. At the same time, because of its low solubility, Natamycin is usually used for food surface preservation. Biological preservatives.

cheese

Natamycin prevents mildew in cheese during ripening to limit the formation of mycotoxins. Because it is difficult to penetrate into cheese and only stay on the cheese surface, it has advantages in controlling the growth of mould on the cheese surface and does not affect the ripening process of cheese. There are three specific application methods: 1). 0.05%-0.28% Natamycin is sprayed on the surface of cheese products 2). The salted cheese is soaked in 0.05%-0.28% concentration suspension for 2-4 minutes. 3. 0.05% Natamycin is added to the coating covering cheese.

Cantonese-style mooncake

Moon cakes are rich in nutrients. Mould often happens in pie fillings and salted egg yolks. Natamycin has good anti-mildew effect on moon cakes. Spraying method is usually used: Natamycin product is prepared into 0.02%-0.04% suspension. When the moon cake is baked and cooled to room temperature, Natamycin suspension is sprayed on the surface and bottom of the moon cake, which can complete external mildew prevention. Raw salted egg yolk is baked in oven until it is seven or eight ripe. After being cooled, it is soaked in Natamycin suspension for about 2 minutes to prevent the mildew of egg yolk filling.

Bakeries

Spraying 100-500 ppm natamycin solution on the surface of baked food such as cake, white bread and crisp cake, or spraying natamycin on the surface of unbaked dough, the anti-mildew and fresh-keeping effect of natamycin solution is very ideal, and it has no effect on the taste of the product.

Meat product

The method of soaking or spraying meat food and using 4 mg/cm2 natamycin can achieve safe and effective anti-mildew purpose. Soaking sausage coat with 0.05%-0.2%(w/v) concentration of natamycin suspension or spraying sausage surface filled with filling can effectively prevent sausage surface from moulding. The shelf life of roast meat, roast duck and dried fish products can also be extended by spraying 0.05%~0.1%(w/v) natamycin suspension.

Salad dressing

Salad dressing is a kind of high-fat food, and mildew often occurs after summer. It was reported in the literature that 10 ppm natamycin was added to salad dressing. No deterioration was found during the experiment, and the number of microorganisms did not change significantly. Salad dressing is similar to cheese and has a high fat content. The experiment shows that natamycin has a definite bacteriostatic effect on high fat food.

soy sauce

In summer with higher room temperature, adding 15 ppm natamycin to soy sauce can effectively inhibit the growth and reproduction of yeast and prevent the emergence of white flowers. The combination of natamycin and Streptococcus lactis in soy sauce can effectively inhibit bacteria and reduce the inhibitory concentration.

Drinks

Because of the high content of sugar and organic acid in all kinds of fruit juices, it is very suitable for the growth and reproduction of yeast, which causes the deterioration of fruit juice. Natamycin can increase the storage stability of non-alcoholic beverages. Natamycin 20 ppm was used to prevent the fermentation of grape juice caused by yeast contamination. Adding 100 ppm could completely terminate the fermentation activity. Orange juice is contaminated by fungi under natural conditions. Orange juice usually deteriorates after one week. After adding natamycin, even if the dosage is as low as 1.25 ppm, the shelf life of orange juice can be as long as 8 weeks when stored at 2-4 degrees centigrade. The bacteriostasis effect of natamycin is related to storage temperature. Concentrated orange juice stored at 10 C can inhibit the growth of yeast in it at 10 ppm, while natamycin at 20 ppm can inhibit the growth of yeast when stored at room temperature. Natamycin, 30 ppm of apple juice, can prevent fermentation of apple juice for up to 6 weeks, and the original flavor of the juice has never changed. Natamycin at 70 mg/kg concentration of tomato juice has a good anti-mildew and fresh-keeping effect on tomato juice.

Other

The use of rice cake and steamed bread can prevent mildew and prolong shelf life effectively. Natamycin is used in vinegar and other condiments to prevent deterioration caused by mould and yeast. In beer and wine, 2.5mg/kg natamycin can prolong the shelf life greatly. In addition, adding 5-10 ppm natamycin to yogurt can prolong the shelf life of the product for more than 4 weeks.

Medical use

Natamycin is used to treat fungal infections, including Candida, Aspergillus, Fusarium, etc. It is also used in eye drops or oral medicines. In these applications, the human body absorbs less Natamycin. When taken orally, it is basically not absorbed from the gastrointestinal tract, so it is not suitable for systemic infections. Natamycin is also used in eye drops. Its 5% content is suitable for treating fungal blepharitis, conjunctivitis and keratitis caused by microorganisms, including Fusarium putrefaciens keratitis.

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